| ncRNA name | Miat |
| ncRNA Category | lncRNA |
| ID | 102552664 |
| Ensembl | NA |
| Synonyms | NA |
| Disease name | diabetic retinopathy (DR) |
| Species | Rattus norvegicus |
| Tissues/Cell_line | retinas |
| Methods | TUNEL assay, qRT-PCR, Western blot, in situ hybridization, MTT assay, Hoechst staining, luciferase reporter assay, Calcein-AM and PI double staining |
| Expression pattern | up-regulated |
| Functional description | MIAT knockdown obviously ameliorated diabetes mellitus-induced retinal microvascular dysfunction in vivo, and inhibited endothelial cell proliferation, migration, and tube formation in vitro. MIAT functioned as a competing endogenous RNA, and formed a feedback loop with vascular endothelial growth factor and miR-150-5p to regulate endothelial cell function. |
| PubMed ID | 25587098 |
| Year | 2015 |
| Title | lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA. |
| Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.